L-Arginine, Citrulline & NO (Nitric Oxide): BP & ED – FORD BREWER

L-Arginine, Citrulline & NO (Nitric Oxide): BP & ED – FORD BREWER


Hello. Today we’re going to talk about
arginine l-arginine some of you may recognize that that term from other
videos I’ve done recently on citrulline in fact there’s a debate in the internet
about whether tea for people that want to take supplements in this space
whether it takes citrulline as a supplement or arginine
I’m not going to get into that today I made in a later video but why is there a
debate over those two because they go to a common endpoint an endpoint called
nitric oxide so I am going to talk a little bit about nitric oxide why that’s
important the discovery of nitric oxide and whether or not l-arginine actually
helps but first a brief introduction my name is Ford brewer I’m a doc I have
been in prevention preventive medicine for a long time this is a channel about
preventive medicine the science behind preventive medicine I had a viewer
complain recently that I talked a lot but didn’t tell him what to do I’m not
going to tell you what to do on this channel you can find out what to do in
plenty of places on the Internet this is more about the science the
background giving you the facts so you can decide for yourself what you need to
do in terms of longevity and prevention so I mentioned nitric oxide we’ve known
about nitric oxide for a while in fact if you look at this article out of
circulation 1998 they’re announcing this is about the the Nobel Prize for
medicine that year and and it was for nitric oxide discoveries here’s a few
things about it it went to three scientists dr. Robert furchgot at SUNY
I think dr. louis ignarro in la and doctor Farid Murad I think it in
Texas they received the 1998 Nobel Prize and obviously in Stockholm and then came
back to the states and did some some other things and I’ll describe what one
of them did in a few minutes twenty years before that doctor furchgot at
suny began studies back around 1980 and what he found was there’s a substance
made by the endothelium the intima you may remember that I’ve mentioned it many
times in many videos the endothelium he said creates a chemical it’s a signaling
chemical and it relaxes vascular smooth muscle cells remember that’s the media
so the the intima is making a chemical that relaxes the the media when you
relax the media that’s going to lower the blood pressure and it’s going to do
a lot of very interesting things dr. Murad in an unrelated set of experiments
at the University of Texas in Houston was analyzing how nitroglycerin works in
1977 he found that the nitrates released nitric oxide which releases which
relaxes those smooth muscle cells resulting in vasodilation in fact we
still use nitrates one of the classic things when I went through Medical
School was use of nitrates for angina heart pain associated with plaque in the
coronary arteries he was fascinated by the colorless odorless gas and the fact
that a colorless odorless gas could be a signaling chemical within the walls of
the arteries now dr. ignarro who was now a professor at UCLA in medicine in
California concluded through a series of experiments that this chemical the
endothelial cell produced this endothelial cells smooth muscle
relaxing factor or EDR F that was described in the beginning by dr. furchgot in Texas he called it endothelial endothelium
derived relaxing factor that’s what he called it
meanwhile over in LA dr. ignarro identified endothelium derived
relaxing factor and he said it’s nitric oxide so some very interesting pieces of
research and they also connect some dots that i think a lot of people didn’t know
that citrulline and arginine are all related to the nitrates nitroglycerin so
we’ll talk about those briefly in a few minutes before we go on I mean before we
do that just a couple of other comments about the Nobel Prize that year Michael
DeBakey the heart surgeon was the chairman of the Lasker Award jury and
there had been some back-and-forth about there were a lot of scientists involved
in these discoveries around nitric oxide and there was some some Doc’s were were
included in the Lasker Award some doctors were included in the in the
Nobel Prize award but again there wasn’t total overlap there was some Jawigng and
back & forth doctor forgot who was 82 years old said you know what I’m just
surprised to have gotten the prize usually the nobel prize goes to
something there’s a lot more popular than molecular research I’m just an
old-fashioned pharmacologist now DeBakey I mentioned him a minute ago he
made the point and this is this is a critical point this work all of this
work going around nitric oxide is very important because it’s a fundamental
finding affecting circulation it’s a fundamental and important
observation so if Michael DeBakey said that about
nitric oxide and arginine and citrulline are precursors of nitric oxide now you
start to get some understanding of why people are so interested in those
supplements okay so enough about the Nobel Prize other than to just give you
a picture of one of the winners I’m not going to go into the pictures of the
other winners here’s dr. ignarro actually I will show you the pictures no
I want dr. ignarro you’ll see them again in a few minutes now let’s go to
arginine here is a does arginine actually work so we’ve got some
theoretical background this is a study on the effect of oral arginine
supplementation on on blood pressure it’s a meta-analysis you remember that’s
where a meta-analysis is where you find a lot of other studies that have been
done and you analyze you create a study of those studies so you analyze you get
a lot bigger numbers that way some of the smaller studies may not actually
they may not be good they may have bias they may not be totally looking at the
same research question so you have to go through all of those issues when you do
a meta-analysis this a meta-analysis was part of the Cochrane central register of
trials they used the Cochran study information they used information out of
clinical trials comp so don’t go so these are both really good resources and
you would think the you know so far as you start looking through the science
here the science is pretty good what did they find
well the results was this compared with placebo l-arginine interventions
significantly lowered blood pressure five point three milligrams mercury systolic and two point six six diastolic
here’s another thing you whenever you see studies you’ll also see these
numbers P equals or P is less than and that’s the probability of this occurring
in these studies by a random event is less than so the p-value is very good on
these there were less than 1/10 of 1% so that sounds pretty good right
well I tell you you get a much bigger decrease in blood pressure from
the from a lot of other medications but a lot of people don’t want to take
medications they’d rather take supplements things that have not been
researched and and pushed by big pharma things that have not gone through safety
trials by and reviewed by the FDA and I understand fully so if you’ve got a mild
impact on your blood pressure that you’re looking to get and you want to go
supplements versus medications that’s what the science says I’ll get back to
those in just a minute before I do though just wanted to make a brief
comment regarding nitrates if you look up nitrates and nitroglycerin you’ll
find that nitrates have a significant impact in a couple of different ways
they release the they dilate the veins so you get a decrease with blood
returned to the heart you get it that’s called a decreased preload that
increases the ventricular load that decreases the wall tension in the
ventricles and so again that’s how nitric oxide from nitrates or
nitroglycerin helps with angina excuse the coffee I’m I do take ramipril by the
way and sometimes I do get a call that’s an ACE inhibitor that’s another way of
decreasing your blood pressure at higher doses nitrates will actually even dilate
arteries if you dilate arteries since just veins you’re going to decrease
peripheral resistance and therefore afterload as well in other words
decrease the load coming into the heart also decreased the load the heart is
pushing against so again how many people do you know or have you heard of that
had angina and we’re taking nitrates again that’s what we’re talking about
here relaxing the artery walls relaxing the veins relaxing the heart so back to
arginine for a minute arginine is a supplement this is another
study effective long-term oral arginine supplementation on glucose now this was
not this is in diabetes and obesity metabolism 2012 October by Montild and a group and this is not a meta-analysis like the other two this is
just a clinical trial basically what they did was they took a hundred and
forty-four individuals they gave them arginine 6.4 grams per day on average
for 18 months plus a 12-month extended period did they get an improvement in
diabetes or insulin resistance the answer is yes they did not get an
improvement in the probability of becoming full-blown diabetic they did
get an improvement however in the probability of return to a normal
glucose tolerance now how should we and again fairly good p-values on this less
than 0.001 less than a tenth of a percent how do we interpret that those
of us who work with diabetes and insulin resistance a lot can tell you look if
the pancreas is shot your the islets we call the islets of
langerhans the the part that produces insulin if that’s shot there’s really
not much you can do for it but if you’ve got mild problems with insulin
resistance and therefore pushing your your pancreas harder than normal with
some changes like lifestyle changes and maybe even with arginine you can get
some evidently maybe get some improvement how much of an improvement
again it’s sort of like the the picture with the blood pressure not a lot but
some people really prefer supplements to to medications so another question about
research around arginine this is safety and performance benefits of arginine
supplements for military personnel this was also a meta-analysis basically this
looks like their point was these people were in their military this was
published in nutritional review 2016 November and they’re saying look a lot
of military people are taking arginine supplementation does it work does it
help in terms of performance their answer was no they reviewed 2687
articles most of them were not so good research and were dumped they did use
sixty-two articles in terms of meeting all the inclusion criteria in in other
words they didn’t see a lot of risk of bias consistency directness precision of
the of the research here was their summary l-arginine supplementation
provided a little enhancement of athletic performance or improvements in
recovery short-term supplementation with arginine
may result in adverse gastrointestinal and cardiovascular effects the GI I
don’t think it’s a very serious one I will investigate maybe and do something
a little bit deeper on potential cardiovascular effects so again maybe not so good for
performance they were actually seeing maybe the opposite effect in terms of
not minimal improvement but they thought maybe some risk in terms of
cardiovascular so again I’m not going to tell you what the heck arginine or not
I’m going to tell you a little bit about the science and as usual there’s
confusion there’s mixed signals within the science you remember I told you
about dr. ignarro he went to Stockholm to receive his Nobel Prize and then he
came home he got a job with Herbalife so he actually made a quite a few
advertisements for an Herbalife product called and here he is in his herbal life wearable billboard cycle cycling shirt
and I think the product they were called they were selling at that point was
called Night Watch and his point was yes you can really increase your nitric
oxide and it’ll do a lot of great things for your health so here’s part of the
point if you win a Nobel Prize and I have not – a lot of people are going to
listen to you about whether to take something as I said before I’m not gonna
tell you whether to take something or not I will just tell you a little bit
more about the science and again unfortunately the science is not always
that clear thank you for your interest

76 Replies to “L-Arginine, Citrulline & NO (Nitric Oxide): BP & ED – FORD BREWER”

  1. in sport supplements now they put citruiline instead arginine, they came with norvaline and sustamine, does his make a defference

  2. Some might wonder how medications like viagra use nitrous oxide. A weird side effect? A very popular and lucrative use of NOx? Running? Sex? In conjunction with beta blockers, just kidding.

  3. How does it work?

    L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body.

  4. Interesting…when taking Citrulline i feel like garbage. I've trialled different doses, food with it etc… But ultimately have stopped using it as i feel like i've been poisoned after taking it. Takes 20-40 odd mins to clear before i can do much. If taken before training i get sweaty and very queezy and more often have to stop till its passed. L-Arginine however i don't get any such symptoms regardless of dose and how i take it. I do feel i've had a very good sleep after taking it at night before bed and wake up with alot of energy. Particually noticable during nights where i've had alot less sleep and normally would be sluggish and tired the next day. Also seemingly after a hard, intense day of training the next day i feel good to go, my joints feel well rested, good energy levels etc…

  5. I don't think I'd use anything the Military studies ….They cannot be trusted to look out for our highest good.

  6. Many of us prefer supplement s to drugs because of the intrusive side effects of drugs. Statins put me in a wheel chair. Two days off the drug and I was walking normally. Supplements are food. I know, poison is in the dose but it's damned hard to overdose on food.

  7. you sound very trust worthy, thank you very much. You don't talk to much, you give a lot of good info. Most of those who talk to much, say not much. You do. Thank you, once more.

  8. My question would be: whether or not it is better to take citrulline, which the body, as some say, turns it into Arginine?

  9. I enjoy your videos. It's called " Night Works " not night watch. .. you are so accurate and clear , I was surprised you misspoke that. I sensed a little resentment too. At any rate you are much appreciated for your work. I have some miraculous photos of a surgical procedure that went bad, then I used Aloe, concentrate . In 24 hours the change was dramatic, Respectfully , KR

  10. Quite Informative. Thanks for sharing the Science behind Nitric Oxide . My experience with L Arginine & L Citrulline has been all positive for someone who was on 3 blood pressure & statin medication. I have seen great improvement in my overall health . Not only does "NO" support your Blood Vessels but it also melt away any cholestrol plague caused by a dysfunctional endothelium. it also prevents blood platelets from sticking together. however it boils down to the quality of the supplements that you use as all supplements are not created equal as well as lifestyle changes of course.

  11. let me get straight to the point… which one is better? I got headache between which one to take… I would use it in training

  12. Thank you for you video. Is it possible that the AC in the room is drying out the air too much and making your throat dry? I notice that this happens to me especially in cars with great ACs. It's a pain when you have a lot to say. Aloha

  13. I have taken a lot of products over the last years initially because I had borderline blood pressure and i didnt want to start BP medications. L citrulline in my personal belief is the only thing that has given me positive results after much experimentation. I tried beet root powder, but it has a terrible taste. I have seen a new product on the market and it is called oxyspark, but im a little intimidated because I hope it doesent have negative side effecst. If I do try it I will report back what I think about it. great channel

  14. one interesting aside with your experience may come from. present study suggest that the l-arginine–NO pathway is deeply involved in ketamine's antidepressant actions and that the downregulation of brain T-NOS, iNOS and eNOS activities contributes to ketamine's antidepressant effects on rats in the FST.

  15. Boil beetroot and mix it with banana and kiwi, garlic , boiled down citruline found in the white part of the watermelon and 3 gs of l argine.

  16. Dark chocolate, 80% or more cocoa solids approximately 30g per day, helps to increase NO….Better still, take it with a pinch of ginger spice and mango or kiwi in the evening. Synergistic combination. Enjoy. X

  17. When taking L-arginine and Citrulline – I've noticed increased endurance and performance when weight training. I am able to get more reps and my respiration is improved.

  18. Dr. Ford Would you cover at some point the reasoning behind the medical advice to not take L-Arginine after a heart attack? https://www.nutraingredients.com/Article/2006/01/04/L-arginine-may-be-harmful-for-heart-attack-patients Doesn't make sense?

  19. I really like your videos. Pure substance, to the bone, no hype. Along with some few others on youtube, you are giving pertinent information that is easy to understand even for a layman.

  20. Thanks for the information.
    I have been taking 3g of l-citruline/malate for a year now. I find it does lower my BP for not more than 8 hours but so do my BP meds. I'm taking for improving circulation in my extremities. I'm seeing some real improvement but because I have other supplements I can't be sure of its individual benefit. I do know that I'm not willing to give it up.

  21. I have a question regarding this..would NOX have a negative impact on varicose veins? If they work as vasodilators, isnt that something you want to reduce if you have varicose veins? Or does the NOX only work in arteries?

  22. Thank you for being a nice guy and not another arrogant doctor. You have a lot to boast about and still seem down to earth. You're not afraid of new ideas or to admit you're wrong . You have strong character .

    Albert Einstein: "Any intelligent fool can make things bigger, more complex, and more violent. It takes a touch of genius — and a lot of courage — to move in the opposite direction."

  23. Amino acids are hugely important… After all , the purpose of DNA is protein synthesis… If DNA is important, protein is important and therefore amino acids are important…. And I am AMAZED by peptides even more…
    .

  24. As far as type 2 diabetes, why bother with supplements when it can be reversed? Most people with diabetes can either reverse or greatly reduce their medication simply by reducing their carbohydrate intake. Take a look at the published research Sarah Hallberg has done. https://blog.virtahealth.com/low-carb-research-comprehensive-list/ She is only one of many doctors who are now using a low carb diet to reverse type 2 diabetes.

  25. doc I really love your channel you are my hero , I actually got an ED (am 29) due to over masturbation and I was prescribe nitric oxide to resolve that ,

  26. Dr. Brewer, I saw your videos on arterialsclerosis, and found them interesting. However, I am somewhat concerned about this video. I have suffered from psoriasis since childhood, and have done a good deal of reading of published research papers. I have also done personal trials of many supplements and herbals, in various combinations. The interesting thing bout psoriasis is that you quickly see any negative reaction to a supplement or herbal. You do not need any lab tests. The results are plain to see in from of your eyes.

    I have tried supplementing with both arginine and citruline. Both cause a severe negative reaction, dramatically worsening psoriatic scaling and shedding of the skin. This does not bode well for other diseases with similar altered chemistry, like other autoimmune diseases, cancer, and possibly even arterialsclerosis.

    Why, you might ponder? Well from the research that I have read, symptoms of psorisis are associated with the expression of an enzyme called arginase. This competes with nitric oxide synthase for the supply of arginine. Since citruline is readily converted to argine by the body, the same appears to apply to citruline. The resulting product of arginase acting on arginine is ornithine. Ornithine is a precursor for the creation of polyamines which are apparently what fills cells. The increase in polyamines results in bloated cells, which would be in preparation for cell division, and proliferation. Looking at psoriastic cells under a microscope, you can clearly see bloated cells. So, arginine in the presence of all diseases where arginase is expressed results in increased cell division.

    So what is going on? In autoimmune disease and cancer, the effected tissues are suffering from hypoxia. Hypoxia is low oxygen supply, which results in chemical changes in the effected tissues.

    These chemical changes appear to be very telling. Of interest is that these same changes occur in wound healing, where the rupture of blood vessels decreases the oxygen supply to injured tissues.

    One of the changes is the expression of vascular endothelial growth factor (VEGF). This is an attempt by the affected tissues to grow blood vessels, to increase the blood supply and so the supply of oxygen. Another change is the expression of arginase, which helps in cell division, to grow new cells, and not just vascular cells. Wound healing also requires the growth of other cells to close the wound and restore normalcy. Inflamation, and an immune response also occur in wound healing, as well as in diseased tissue.

    The implication is that these diseases are a manifestation of a wound healing type response to low oxygen levels. When these actions do not result in an increase in oxygen levels, cell proliferation spirals out of control and you have a disease state, since the body keeps trying.

    Treatments using hyperbaric oxygen have proven to be effective and clears up the symptoms of psoriasis for up to eight months. Hyperbaric oxygen has also been shown to be beneficial for other diseases which have hypoxia as a factor. Further, the Dead Sea is located below sea level and has a 5% higher oxygen content in the air, as a result. Extended visits to the Dead Sea are effective in treating the same diseases. Since Dead Sea salts have not been shown to give the same benefits, it is logical to conclude that the therapeutic factor is the elevated oxygen. due to stress reduction, sun exposure, and higher atmospheric oxygen.

    I have personally experienced situations where increased oxygen has had an immediate effect on psoriais, causing miraculous clearing in just a couple hours.

    Now if you think about it, in wound healing you do not want to dilate blood vessels, since that would result in increased bleeding. So, although nitric oxide synthase is expressed, other factors, such as competing arginase, prevent that from happening. The same seems to be true for those diseases.

    So, one might expect that arginine and citruline supplementation might be helpful in the healing of healthy wounded tissues. With diseased tissue, one can expect a worsening of the disease. I submit to you, that any discussion of arginine or citruline supplementation should be accompanied by a warning for those suffering from these diseases.

    A better approach would be to use the neurotransmitter pathways to dilate blood vessels when that might be therapeutic, for increasing blood supply.

  27. Hello Dr Brewer,

    I discovered Dr Ignarros book," the arginine solution", and another book about niacin in 2002 after a procedure to install several stents. I have genetics from both sides of my family for diabetes and heart issues and thought I had a pretty good lifestyle also.
    I was an engineer at Abbott labs and my wife was also. The high pressure nature of our jobs caused a great deal of health issues.
    I retired in 2002 with health issues and went to the local library with my young children for book reports and found the healthy heart section. Arginine, niacin , alkaline water and a blood type diet, I'm A. All helped immediately. First time in 10 years with no chest pains, which I thought was gas or stress.
    A life changing event.
    I was getting divorced, had left my dream job and struggling with many problems.
    I came to the conclusion that I was ultimately responsible for my own health and made huge lifestyle changes. As a single Dad with the internet at my finger tips laying on the couch recovering from surgery. I began to study all my and family and friends health issues and preach to them. With mixed results.
    Its been over 16 years and I'm still going having recently impressed my cardiologist with a stress test result.
    I'm a little concerned about my 45% blocked carteroid arterys but overall I'm better.
    I have an abdominal aneurysm that's almost 5cm and will require attention soon before I build my last new house this summer but pretty good for 71 years old.
    I build energy efficent houses and cars and teach others how. I give GOD the credit for my life having brought me through a hard childhood, the Viet-Nam war, and maritial hardships.
    I tell folks that heaven doesn't want me and hells afraid I'll take over and that's why I'm still kickin.
    Thank you for your great video series and I hope you touch many lives as you have reaffirmed my research to good health.
    Charles H. Bryan

  28. Very nice information and really enjoyed the video. My brother is a doctor and we talk all the time about these type of things. I actually experimented with L Arginine just the supplement alone and not using any other supplements with it. I had some of the best craziest muscle gain I have ever had. I'm a certified trainer and used to own a gym and have been working out for 19 years now. I started off taking just 2-3 grams a day and then moved up to 9 to 10 grams a day. The strength and muscle size I put on was absolutely insane. People thought I was taking steroids. I think it was due to the improvement of blood flow that allowed more nutrients to flow through the body and it must have stimulated my natural Human growth hormone at those high levels I was taking of Arginine is my first thought. I don't recommend people to do that but it worked wonders for me. I would do that and get off if for a bit and then slowly start upping the dosage again really high. I have been natural my entire life and I must say its the best results I have ever had as far as muscle size and vascularity and my energy levels were really good. Thanks for the video Doc and You might know Dr Eric Westman from Duke. My brother had the privlage to kind of shadow him about the keto diet as well. My brother Graduated a while back from Brody School of Medicine ended up being the highest scoring class they ever had in school history. We come from nothing so I am very proud of him thats the only reason I am mentioning that and your a doctor too.Thanks for the great video SIr!!!

  29. Dear Dr., if you would stop showing those writings, you would do us a great favour. No one can read them the way you show them and distracts our attention to what you are saying. Don't be so insecure, you do not need to justify your arguments that way, there are other ways, like giving us written references to read after your exposition. Thank you!

  30. I have been taking 1000mg of l-Citrulline and 500mg of l-arginine 2tms/day for 3 weeks. I just had my Potassium level tested and it has raised out of the normal range to an unsafe level. My question is this: which has greater effect on raising Potassium levels l-citrulline or l-arginine?

  31. Very good video……..relaxing factors such as beets, arugula, garlic, cayenne pepper also help, and other natural substances…..to open your vascular pipes….thank you Dr.

  32. I had an unusual but not unknown reaction to arginine – I began to have swallowing difficulties. At first I wasn't sure arginine was the cause but I replicated the reaction. Meaning I stopped arginine and the problem went away, then months later tried taking it again – with the same result. Oddly, citrulline does not cause the problem.

  33. Hello again Dr. Brewer,
    I've been following every one of your videos and changing my supplements regimen based on your and many other sources.
    Dr Ignarro wrote a second book called I believe ,"NO more heart disease". Saying to also take L-Cittruline. He added to his previous study ," The arginine solution", saying they work synergisticly and compound the effect. As I had very good luck with his advice in the past, I added this to my daily schedule.
    I of the interesting statements Dr. Ignarro made about L-arginine was power lifters discovered it as steroids were illegal. He stated that the NO would dilate the red blood cells, allow the lactic acid to escape and oxygen to enter increasing the strength of the user. I found this to be true for me as I was recovering from stents.
    I left Abbott after our ethics didn't match on so many drugs and cures, so I'm pro supplements and as per your video I will resume taking statins again to hopefully reduce arterial plaque in carotid arteries and after surgery to repair an abdominal anuersym, step up my strength training.
    I'm sad that Dr Ignarro has caved in to big pharma for profit.
    I'm also disappointed in the Nobel group for awarding the prize to President Obama for a promise that was not kept. It has tarnished his and their image.
    Thank you again for bringing your good news to the masses.

  34. arginine with citrulline stays in your system all day it lowers high blood pressure all day!!! citrulline is the key to mix with arginine

  35. Walgreens has Libido-Max Red which is a nitric oxide performance booster for about $10.99; on sale it's $8.99. It does contain L-Citruline, L-Arginine, Beet Powder , and Black Tea Extract. Serving size is 2 to 4 tablets taken an hour before workouts and sex. Be careful if you have high blood pressure or heart troubles. It does help. I have used it in the morning with my sex partner before she woke up. Took it less than an hour before she woke up and I experienced a hard-on like I had when I was in my 20's. I am 63. Quite a treat for both of us!

  36. Yes it works , but last time i was out , all i could find l arginine with something else , you had to buy 2 so i spent my money on them, the second product causes me to feel aggression and irritability. So i have abandoned them .

  37. I always start with the minimum dose because everybody is is different. I am sensitive to meds and supplements so I don't need much.

  38. What are your thoughts on low carbs higher vegan healthy fats vs higher vegan carbs, low fat with respect to preserving pancreatic function for moderate type two's?. Thanks

  39. Thanks Dr Brewer another great presentation . You have a gracious heart that i'm sure will serve you well . Yours D.C.H. Tauranga New Zealand

  40. I just started adding 1g l-citrolline to the 5g l-arginine to my pre & post gym resistance training workouts. I take it in Premier Protein choc. shake of 30 g protein, 2 net carbs, along with 2g vit C, 30 ml brewer's yeast, hawthorn berry powder, butcher's broom for varicose veins, choline, etc.
    I can tell the increased ease of doing 20 reps on the 8 machine leg workout with full loads.
    I was curious if I was getting desired reduction in BP. But when I tried to measure, reminded that machines often don't read my anomalous pulse SBP correctly. Should read abt 120/80; I want it down to 119/79 or less, just 1mm to get below the range boundary.:-)
    I had T2DM, but so far no eye or kidney damage, but ED. Whereas viagra helps with hydrolics, workout cocktail helps with nerve enhancement and desire stimulation. But then the cocktail has horny goat weed, which is wild.
    I am "untrained", so my experience seems to agree with earlier citrulline article you reviewed.

  41. Hey, nice video. I have question, i recently use some preworkout which has citrulline and creatine, and my hair start to fall off. So i know that creatine can cause loosing hair but i dont know about citrulline since it does almost he same thing increase atp whuch leads to increasing DHT which leads to loosing hair. So am i right? Is citrulline safe for hair?

  42. For arginine to work you need to take at least 5-10 grams per day for it to work,depending on body weight.There is also lcitrulline and lcitrulline maleate in many bodybuilding pre workout supplements.They also include agmatine sulfate,l nor valine,l taurine and other ingredients like beta alanine and betein androdrous, beet root powder extract etc

  43. Looking to this Video explain a lot to what happens to me few days ago, I had heart attack 4 year ago , so I been taking Losartan 100mg (1 time a day) and Metropolol 2 times a day, I been OK, few days ago I got a bottle of L-Citrulline 750mg and start taking 1 pill eveyday in the morning (because I read it help to clean the arterries?), 3 days later my heart when down to +/-42 BPM and night my blood pressure was around 90/60 , in some moments I was feeling very very bad so I stop taking the L-Citrulline and recover, not taking L-Citrulline anymore so I know was the effect of the L-Citrulline plus the Losartan and Metropolol doing that, Make me ask what could happen to some body taking L-Citrulline daily and mixed with Viagra for example could be dangerous?????. Thanks for the Info great work.

  44. My experience with 3 grams a day off and on for over 10 years. It's for athletic performance. I do not see this supplement doing anything for anyone who does not use a lot of the chemical it provides in the body already. I push it past it's current limit so I have seen a need for supplementation. However in 98% of humans there is likely no need to supplement this. Thank you as always Dr.

  45. Really great vids…but Dr, that cough sounds like a Ramapril cough…..have a word with your Doc..keep up the good work…

  46. Ive been taking L-Arginine for 10 years. 10 years ago i had serious heart palpitations and high triglycerides along with very uncomfortable Vital records.

    Now i have the best Vital records 110/50 at best. But…..

    The Amino acid L-Arginine in my system functions in two different ways.

    The most noticeable is when i am active in exercise and stretching. My heart vitals slightly increase, entire body is oxygenated and my endurance is like an Olympic athlete. People at the gym are curious about my athletic they don’t know that its a process. A complex process far from just popping a couple vitamins.

  47. I enjoy your knowledge, am new subscriber. The alkaline in L-citrulline is effective for me personally to reduce congestion. it also gives me more energy in general. I put 1-2 scoops of it in water — and it it has a pleasant tart taste.

  48. Should we take each supplement separately, or is it okay if we take a pill with both ingredients in it? What's more beneficial?

    Thank you.

  49. hello. looking for information related to the use of MCT oil and l-Arginine together for pre workout. taking 2x 2.5g l-Arginine /day and 2 teaspoons of MCT. are these likely to conflict at all do you know please? been in ketosis for past 6 months

  50. I respond really well with arginine, citrulline, beet juice, and other nitric oxide supplements, but have you ever heard of other side effects other the cardiovascular disease? Example, I experience an annoying rash. Have you ever heard of the body becoming allergic? I took those a long time before I started to get a rash. Another possible solution, are they bad for the liver and/or kidneys, that usually effects the skin 🤷‍♂️any info would be great. Thank you

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