INSULIN & GLUCOSE RELATIONSHIP part 1 – Type 2 Diabetes #2

welcome to the second video of type 2
today we’re going to look at something very cool but before that I want to
thank everyone that watched the first video and sent messages and you know gave
me motivation to continue what we’re going to discuss today is the
relationship between glucose and insulin now if you go on YouTube and look for
insulin you’ll have maybe more than a thousand videos on insulin and what most
people will tell you is that insulin is the key that unlocks the door for the
glucose to get in to get into the cells but today we will see the real
relationship between glucose and insulin and see who is the boss who is
controlling who let’s say this is a blood vessel I will draw the pancreas it’s kind of ugly but… and let’s take one
beta cell outside so what everyone knows is that glucose will come into
your blood and then the beta cells of the pancreas will produce insulin and insulin will get the glucose into the cells but many people do not know how…
and it’s not like a key that will unlock the door but it’s actually something
really cool let me tell you inside the inside the cells especially muscle cells and fat
cells glucose has its own private jet and we call them glucose transporters they stay inside those cells when insulin binds to the receptor on the
cell on the cell’s membrane there are some
signals inside the cells medical students will understand this but for
the other people just know that cells communicate they communicate within
themselves and they communicate with each other but they don’t use Twitter or
Facebook they have some signaling pathways now this will make these
vesicles that have glucose transporters to move to the membrane to get into the
cells the thing is if we stop here then most people are right that insulin will
get glucose into the cells but insulin does not stop there
insulin is an anabolic hormone anabolic hormone that means it promotes growth
insulin will make you bigger by increasing protein synthesis and even
take some amino acids into the cells increase protein synthesis… that means
you will go from this one to this one insulin can make you bigger insulin
can also promote lipogenesis basically storing fat so insulin it can also take
you from this one to this one and insulin can also promote the storage of
glucose as glycogen and insulin it can also use other pathways like MAP kinase
to promote proliferation it means quick division of cells for example you have
one cell they quickly divide into two quickly into four eight and the list
goes on you see a lot of people saying that insulin can promote cancer… if
something can help them divide obviously you know what’s going to happen right and insulin can also do other things cancer cells are not supposed to survive
because all the cells in your body have something in them that if something goes
wrong with the cell they will kill themselves this is beautiful you know
they sacrifice themselves for the body but insulin can also stop some of that
can also stop apoptosis which if it happens to be a cancer cell you know
but these things we’re not going to discuss here so insulin can make the glucose get
into the cells and can make the cells use the glucose or store the glucose as
glycogen or as fat and insulin can also make the cells take amino acids and
fatty acids for example that’s why those patients that have a lot of insulin in
their blood are normally obese or fat because insulin can make you fat can
make you bigger can make you grow can make your cells stop dying even if there’s
something wrong with them and can make your cells divide quicker and become
larger and many so this is clear but then who makes insulin come from beta
cells this is the important question because if the beta cells just release
insulin for no reason then we can blame the beta cells and say why are you
releasing all this insulin if you know they would make us fat but actually
beta cells do not release insulin by themselves on the surface of beta cells
there are some private jets glucose transporters on this one we call them glucose transporter 4 and they are
inside the cells when insulin binds to receptors they are moved to the membrane
but for the beta cells they are there already glucose transporters 2 so when
the glucose goes up after you eat glucose will just get in for free
now here glucose will go into glycolysis and through a lot of steps just know
that at the end there will be productive energy in the form of ATP and
these ATP see what they will do on the surface of the beta cells there are also
some channels called potassium channels and these channels normally allow
potassium which is positive to go outside of the cells so that the cells
can cool down but this ATP will block this channel so the potassium will not
go outside and the cells will get more positive now there is another
channel… the last one… calcium channel calcium channel… these calcium channels
they’re voltage sensitive when the cells get hot they will open and a lot of
calcium will get in… lot of calcium will get in and this will link the
insulin which was already here to the membrane this is what the calcium
would do then the insulin will get released into the blood so what did we
see here that insulin can promote growth can promote proliferation can promote a
lot of stuff but glucose is the one that gives orders to the better cells to
release insulin because when glucose gets in everything else that happens is
automatic so at the end of the day who is making you fat now write your comments
down and tell me who is making you fat the insulin that promotes all this or
the glucose that is making the insulin promote all this that’s why sometimes
after church we go somewhere to eat with friends and I don’t drink any
sugary drinks they keep asking me why why why and sometime when I don’t go they
say ok he’s not here today so we can enjoy our drinks but the thing is I
can’t because I know that those things are high in sugar they will get into my
blood they will go into my pancreas and they will force my pancreas to release
insulin insulin will get the glucose into the cells and amino acids into the
cells fatty acid into the cells and will promote storage
of fat here and here and here and here and apart from that these pathways can
also stop the use of any storage that you have it doesn’t matter if it’s
glycogen it doesn’t matter if it’s fat if you have fat stored here insulin will
stop the breakdown of those fat so you will stay fat and then it will make the
cells put some more fat with this understanding if you give sugar drinks
to your children do you love them or you hate them I know this is a deep question
but just write them down I want to see them anyway if you do it once in a while
it’s okay but if you do it often just know what you’re doing to yourself just
go to your calendar and start cutting days say okay today hmm I made my life
shorter by five days and tomorrow – one day – ten just keep doing that every
time you drink those stuff you know why I enjoy these things because before I
got into the medical school I was very afraid of diabetes because in my family
a lot of people have diabetes and some have died with diabetes so it was
something that I always had inside I knew that this was something that you
know we were supposed to go through but after understanding what’s really going
on I can tell you confidently that I would not have type-2 diabetes because
this thing is easy to fix so if you like this video can give your thumbs up and
subscribe and allow the notification so that when I release the next one you
will you will know… be blessed… bye

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