Herpes (oral & genital) – causes, symptoms, diagnosis, treatment, pathology

Herpes (oral & genital) – causes, symptoms, diagnosis, treatment, pathology

Most of the time, when herpes simplex virus
or HSV infects a person, there are no symptoms. In fact, it also usually moves from one person
to another in the absence of symptoms, so it can therefore it can move through a population
silently. Once in a while, though, it can cause symptoms, and typically those are in
the form of skin and mucous membrane lesions which can be divided into infections “above
the waist”—mostly involving the mouth and tongue, and those “below the waist”—involving
the genitals. There are two types of herpes simplex viruses—HSV1 and HSV2—both of
which are part of a larger family of enveloped double-stranded DNA viruses: the herpesviridae
family. Generally speaking, HSV1 tends to cause infections above the waist and HSV2
tends to cause infections below the waist, but there’s a lot of crossover because both
viruses can cause both types of infections. Although herpes is most contagious when there
are virus-filled lesions present, it can also spread by asymptomatic shedding which means
that herpes viruses can be in saliva or genital secretions even when there are no signs of
a cold sore or genital lesion. Typically, when herpes virus lands on a new host, in
other words a person that’s never had herpes before, it dives into small cracks in the
skin or mucosa and binds to epithelial cell receptors, which triggers those cells to internalize
the virus. Once inside, the virus starts up the lytic
cycle, which is where its DNA gets transcribed and translated by cellular enzymes which help
to form viral proteins which are packaged into new herpes viruses which can leave to
go off and infect neighbouring epithelial cells. HSV1 and HSV2 also infect nearby sensory neurons,
and travel up their axon to the neuron’s cell body to start up the latent cycle. The
sensory neurons of the face have their cell bodies in the trigeminal nuclei and those
around the genitalia are located in the sacral nuclei. So that’s ultimately where the herpes virus
settles in—for life! You see, the sensory neurons aren’t destroyed, instead, they
become a permanent home for the herpes virus, and from time to time, the herpes virus makes
a few viral copies of itself and sends those virus particles back down the axon so they
can get released and infect epithelial cells. Since the trigeminal and sacral nuclei serve
just one side of the face or body, herpes vesicles and ulcers develop on the ipsilateral
or same side as the affected nuclei. This can happen over and over again throughout
a person’s lifetime, with classic triggers being things like stress, skin damage, and
viral illnesses. Recurrent episodes are usually less severe than the primary infection, and
sometimes there are no symptoms at all. When there are symptoms, there might be a characteristic
tingling or burning sensation, called a prodrome, one or two days before the blisters appear. In oral and genital herpes, the primary infection
is most often asymptomatic. Having said that, in oral herpes when it does cause symptoms
it usually affects children and it causes lesions on the palate, gums, tongue, lip,
and facial area, as well as a fever and enlarged lymph nodes. The lesions themselves are typically
clusters of small, painful, fluid-filled blisters, that ooze and ulcerate, and then eventually
heal after a few weeks. In older children and adults, a common symptom is pharyngitis.
Most of the time, like primary infection, reactivation doesn’t cause any symptoms,
but when it does, the most common pattern is having a handful of blisters at the vermillion
border—the border of the lip—on one side of the face. These blisters are typically
smaller and heal over a week. With genital herpes, primary infection can
cause symptoms like ulcers and pustules which form on the labia majora, labia minora, mons
pubis, vaginal mucosa, and cervix in women and on the shaft of the penis in men. Like
oral herpes, most of the time reactivation doesn’t cause any symptoms, but when it
does, the most common pattern is to have a few blisters that resolve rapidly in about
a week. In addition to oral and genital infections,
HSV can also affect other areas. When it affects the fingertip or nail bed, it’s called herpetic
whitlow, and this might happen if the finger rubs up against an active lesion around the
mouth or genital area. Once it affects the fingertip, it’s also easy for it to get
carried over to other areas on the body to spread the infection—a process called autoinoculation. HSV can sometimes involve the trunk, extremities,
or head—a pattern that’s common among wrestlers because they have a lot of skin-to-skin
contact; and is therefore called herpes gladiatorum. Finally, individuals with burn injuries or
with atopic dermatitis can have really serious herpes infections in those areas, the latter
even has a specific name—eczema herpeticum. HSV can also affect the eye causing keratoconjunctivitis,
which is inflammation of both the cornea and conjunctiva. In addition to symptoms of conjunctivitis
which are pain, redness, tearing, and sensitivity to light, there can some classic signs of
corneal involvement like blurry vision and a branching dendritic lesion which looks a
bit like the tree-like dendrites of a neuron, which happens on the cornea itself, and this
pattern is classic for herpes infection. In rare cases, herpes viruses can spread to
the central nervous system and cause meningitis or encephalitis, typically affecting the temporal
lobe, in individuals of all ages. These can happen from a primary infection, but more
commonly happen during reactivation when some of the virus can escape into the bloodstream
and reach the brain. When there is brain involvement, a lumbar puncture often has specific findings
like an increase in red blood cells, increase in white blood cells, and elevated protein
levels. There are also some CT, MRI, and EEG changes that can help to make the diagnosis. HSV can also pass from a mother to a baby.
Rather than causing a congenital infection while the fetus is in the uterus, most of
the transmission happens at birth when the baby passes through infected maternal vaginal
secretions during delivery. Neonatal HSV causes three different patterns of illness each occurring
about ⅓ of the time. The first is skin, eye, or mucous membrane infection, where lesions
pop up 1-2 weeks after delivery typically at sites of damaged skin like the site where
fetal scalp electrodes may have been attached. The second is central nervous system infection
which typically causes lethargy, irritability, and even seizures 2-3 weeks after delivery
and can cause some of the same lumbar puncture, CT, MRI, and EEG findings as that in older
children and adults with HSV encephalitis. If not treated, both the first and second
type can transition into the third type which is disseminated infection, where herpes virus
causes sepsis and failure of various organs including the heart and brain. HSV can cause unique symptoms in immunocompromised
individuals who tend to have more frequent reactivation, more severe symptoms, and a
wider range of symptoms, like lesions in the esophagus or lungs. Herpes can usually be diagnosed based on how
the skin or mucous membrane lesions look, and can be confirmed with tests looking for
viral DNA, like polymerase chain reaction, an antibody response to the virus, or by growing
the virus with a viral culture. Although infections typically resolve without treatment within
a couple of weeks, there are antiviral drugs like acyclovir, famciclovir, and valacyclovir
that can be used topically or systemically to reduce pain and speed up healing. For recurring
episodes, these treatments usually work best if taken when the prodrome starts; in other
words, before the blisters develop, and high-dose intravenous antivirals may be given in more
severe, or life threatening situations. Alright, as a quick recap, most of the time,
herpes simplex virus 1 and 2 cause asymptomatic latent infections that set up in the trigeminal
and sacral nuclei for life, but sometimes they can cause symptoms like recurrent oral
and genital lesions. They can also cause more severe infections like HSV keratoconjunctivitis,
meningitis, and encephalitis, as well as neonatal infections which usually get transmitted when
a baby passes through infected vaginal secretions. Thanks for watching, you can help support
us by donating on patreon, or subscribing to our channel, or telling your friends about
us on social media.

53 Replies to “Herpes (oral & genital) – causes, symptoms, diagnosis, treatment, pathology”

  1. Well you don’t need drugs. Drugs will make it worse in long term. In other words you will die developing another disease by using the drug. Instead.
    Take selenium, stops virus replication, Vitamin C 2000mg twice a day, blueberry stops virus getting close to cell walls, Zinc is necessary for skin health together with selenium. Viruses don’t cause diseases. Now why you get outbreaks? Every time the virus attacks the cell it release toxins, those toxins causes inflammation in the tissues, then those toxins no matter what the body has to release them, the way to do it is by the skin. When the toxins comes out of the body you have lesions. And the most common is a rash, or what its called outbreaks. Boosting the immune system with vitamins will stop virus and you will have the virus kill or sleep forever just like measles, or other viruses inject it by a vaccine. The immune system will ALWAYS WIN over vioand bacteria, the main problem is that, it is not easy to absorb the vitamins unless you do a detox to restore the gut flora. 80% of the inmune system you have it inThe gut. Healthy gut, healthy blood, healthy blood, healthy life. I had a positive test 10 months ago until now, I feel nothing and I haven’t get any outbreaks and I will not have one because of my inmune system

  2. when you have a herpes outbreak it’s because your immune system is down from normal.Keep your immune system up and you will never have a break out ever!

  3. So I been diagnosed with herpes simplex 1 this month and I’m planning on getting pregnant in November ,.,…which is 6 months from now …… will I have antibodies by then and will I have a good pregnancy ???

  4. What if a person who made your food had hsv 1 herpes and had tasted the food and you ate it after they cooked it? Can you catch herpes then?

  5. Well, thanks for the info. This confirms what I've been doing is working. Also because of the natural living, I stop a lot of medications, especially for multiple sclerosis. Yes, you are right, we do need vitamins. We also need to get rid of the toxin stuff we use every day and the food we eat so we don't get sick. The list goes on. The only thing I have trouble is with thyroids, that's the only medications I take.

  6. I've searched hundreds of websites and looked at hundreds of comment sections for herpes and not one person, not a single effing person ever asks if hsv1 carriers can transmit hsv2? Why is this not discussed. Is it common sense?

  7. If you have psoriasis and if you are getting treated with drugs 1.5% of these people treated will develop herpes simplex just because of the drug. That means no you don’t need to kiss or have sex with someone infected with herpes when some drugs can give it to you. But wait a minute, so herpes is it a result of a tissue damage? or is it a result because of drugs made by the pharmaceutical industry. Or maybe outbrakes is not the result of the virus or the virus attacking the body, the outbreaks it’s the result of tissue damage and the skin health. How do I know these, well until now science don’t know exactly how the immune system works, they only have an idea but they don’t know how enzymes works with the immune system. Ummmmm

  8. never believe that I will be Herpes Negative again,DR. IREKO has given me reasons to be happy, i was Herpes positive for 2years and all the means i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about DR. IREKO on how he was able to cure someone from Herpes, this person said great things about this man, and advice we contact him for any Disease problem that DR. IREKO can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he days,and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by DR. IREKO i went back to the Hospital for check up, and now i have been confirmed Herpes Negative, friends you can reach DR. IREKO on any treatment for any Disease he is the one only i can show you all up just contact him on {drIREKO [email protected]} OR Whatsapp +2347087427797

  9. Nice video, very educating and assuring.
    I was once a victim of this virus. Miraculously,I survived. I come from Chicago. Before I asked my girlfriend out late last year, she already told me she was battling with herpes virus. So the decision to get involved with her was mine. But nevertheless, I can't let the virus decide our future. So I was determined to get rid of the virus.
    I suffered from this deadly virus for over 8 months. The lesions were on my lips and later extended to my back. I tried all sorts of meds but to no avail. We spent so much money on meds. To cut long story short, I decided to try out herbal home remedies. Then I went online and I was on one herbal blog, I saw many comments,but after reading about how one herbal Dr. Ugo cured a lady from HSV 2, I had to write the doctor. I contacted the doctor through his email and he assured me that I will be healthy again. He prepared some traditional meds and sent them to me, after asking me some questions. I used all the meds he sent, just as he directed. Though while I was like on the second bottle, I was not experiencing any symptom as the lesion on my back and lips dried up. I continued the dosage and kept in touch with the doctor.After about six weeks,i consumed the whole bottles. I went for test and to my greatest surprise, the result was negative. I was saved the very moment I thought all hope was lost. You too can be healthy again. You should talk to Dr.Ugo through his direct e mail address: [email protected]
    You can also write him on What'App +234-810-499-0619

  10. Go to a grocery store and buy Peppermint & mint extract. Rub it on your sore when it first appears on your lip. It will probably wont come back ever again.

  11. I have atopic dermatitis in 2 years on my sole feet and I take medicine like anti histamine for itching and steroid cream.
    Does it mean I have herpes simplex virus, but I ask the doctor maybe I have virus and he answered no. Just curious 🙄

  12. If you are suffering from this virus and haven't used Dr Jude Herbal Home medicine then you haven't checked out the real solution yet. Herbal formula from Dr Jude is the best

  13. still don’t know the right words to express my gratitude to the Great Dr. Oudo (the USA herbal Dr) After been diagnosed of HERPES SIMPLEX VIRUS in 2014, i was given so many health prescription and advice with no improvement, I totally lost hope, until i found testimonies of Great Dr. Oudo in an online research and on Facebook, Like anybody would be, I was very skeptical about contacting him, but i later did and he opened up to me and told me what was involved and he started the remedies for my health. After he prepared the herbal medicine, he contacted me to inform me, I gave him my address and he told me he was going to send through a courier service company called UPS which I was given a tracking number in order to track the package while on delivery.
    To my greatest surprised, I received the medicine right at my door step in 6 day from the day it was sent to me. He instructed me on how to drink the herbal medicine for two weeks then on the third week he instructed me to go for a test which I did Omg, am still shock by the test result,Thank God, i was cured from herpes by the herbal medication I received from him. I never thought that herpes can be cured, from the bottom of my heart I'm truly grateful,i pray you have long life so you can help many more people on earth with your herbal medical support You that is out there looking for help or cure, you can call or add him on whats-app with this number ( +1 (517) 295 5312 or reach him via email on ( [email protected]) one thing i love most about DR oudo is honestly, his very polite with his customers, everything he told me was what he did, and his herbal medicine are very affordable and confidential whatsapp him on(+1 (517) 295 5312

  14. Natural herbs have cured so many illness that drugs and injection cant cure. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. i read people's testimonies online on how they were cured of herpes, HPV, diabetics etc by Dr Osemekhian herbal medicine, so i decided to contact the doctor because i know nature has the power to heal anything. I was diagnosed with HIV for the past 7 years but Dr Osemekhian cured me with his herbs and i referred my aunt and her husband to him immediately because they were both suffering from herpes but to God be the glory, they were cured too .I know is hard to believe but am a living testimony. There is no harm trying herbs. He is also a spell caster, he cast spell to restore broken marriages and he cast good luck spells to prosper and excel in life. Contact Dr Osemekhian on: /what's app :or call him +2349053460268 you can also email him at ([email protected]) thank you………..

  15. hey mates I want to give a big round of applause to the best Herbal Doc called doc kanayo. I am very happy today, cause have been suffering from herpes since 2017, i have spent a lot on drugs and herbs which has all proved abortive, i have tried all means in life to cure my herpes , but there was no answer until i met Matt Damon who refer me to contact this strong herbal Dr kanayo and he prepare medicine for me after I took his medication as he told me, i am now Herpes Negative,now i am very happy, thanks to Dr.kanayo for helping my life come back newly again without any form of crisis, i promise to tell your name and good deeds to the whole world. Kindly contact him for cure regarding, HIV, Herpes, Cancer and other deadly diseases. reach out to WhatsApp +1 909 375 5642 I will forever remember you Doc.

  16. I've been diagnosed with HSV-1 & HSV-2 for the past 1 year and I'm a father of 3 kids who also got divorced by his wife because of the outbreak of my virus. I was frustrated and hopeless when my wife left me because of my virus. I searched for help randomly but nothing positive came out and my friends were like what else will i do again because they've tried all they could to help me but nothing worked out not until i met a post of Pauline Overton testifying to the world of  how she was helped by Dr Ooza and i decided to give it a try and now i'm a living witness and testifier too of Dr Ooza good works for curing me of HSV-1 & HSV-2.. Get in touch now for any help whatsoever for i believe that he can help you too. Email: [email protected] or WhatsApp +2347050577037

  17. Oh ok good I got it from my mother huuuu that's really good cuz iv never had sex and I'm 12!!! I'm still scared

    My mom has STDs and herpes

  18. With out a doubt more and more children are being born with brain lesions resulting in the increase Of mental deficiency and retardation

  19. I just discovered that I have herpes type one. The only symptoms I get are in the vermilion border of the lip sometimes. and it goes away in a week. Never took any medicine for it.

  20. Herpes Symptom
    What You Need To Know About Oral Herpes

    What you need to know about oral herpes

    Written by Dr Noruwa
    Oral herpes appears in the mouth region. There are two types of herpes simplex viruses. There are several treatment methods you can apply to get rid of the health complication. You do not have to worry about side effects and the treatment procedure is very effective. It is also a cost effective way you can apply to get rid of the health complications.

    Causes of oral herpes

    If one person has been infected with the virus, then he or she can end up transferring the virus to others who are not infected through different processes such as the following:

    Eating from the same utensils

    If you use the same utensil to eat, there are high chances you will spread the virus to the other person if you have been infected. It is necessary to clean the utensils well before you can serve the other person who has not been infected.

    Sharing lip balm

    The viruses tend to stay along the lip hence causing the blisters. If you share the lip balm, it will have deposits of the infected saliva which can lead to the spread of the virus from one person to the other.


    You tend to exchange fluids as you kiss. The act can lead to the spread of the virus from one person to the other.

    Signs of oral herpes

    It is necessary to know the signs of the health complication so that you can take necessary measures to seek treatment.

    Blistering sores

    For the case of oral herpes, you tend to develop blisters along the mouth. The virus causes the outbursts due to their action on the area. You need to start treatment if you notice such signs.


    In some cases you can end up developing fever due to the virus. If you have been developing fever followed by the blisters, then you may be suffering from the herpes viruses.

    Swollen lymph nodes

    Some people record incidences of swollen lymph nodes due to the action of the virus in the body. You need to seek further diagnosis if you notice such changes in your body.


    Sometimes you may experience headache due to the effects of the infection. Other symptoms you can notice include tiredness and lack of appetite. It is necessary to have expert diagnosis before you embark on treatment.

  21. Hi Friends i am so glad to writing this article today to tell the world how Dr odigie cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr odigie the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his whatsApp +2347060751742 orexplained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr odigie that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via : [email protected]
    l. com. or WHATSAPP +2347060751742 GOD BLESS YOU ALL?

  22. I am here to give my testimony about a doctor who helped me in my life. I was infected with HERPES SIMPLEX VIRUS in 2010, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so a lady walked to me telling me why am I so sad and i open up all to her telling her my problem, she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i mail him. He told me all the things I need to do and also give me instructions to take, which I followed properly. And he Prepare some herbs for me that I took and seriously work for me. Then I go for check up and my status came out negative. Contact Dr Oyekpen today for any kind of sickness and disease on his email, [email protected] gmail. com. Call WhatsApp +2349057718445. All thanks to Dr Oyekpen

  23. God bless Dr okena for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2017 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr okena, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3 days. I took the medicine as prescribed by him and 2 weeks later i was cured from HERPES contact him via email once again thanks to you Dr okena. cure the flowing virus, contact his email [email protected] or add him on whatsapp (+2348168455283)
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