EBMT 2018 overview: AML pathophysiology

EBMT 2018 overview: AML pathophysiology


Well the main idea of this session is
to look deeply into the pathophysiology of AML, of how clonal evolution happens
in AML, how we can monitor clonal evolution, and then how we can target it
in terms of treatment. So we’re going to have three speakers. The first speaker is
going to look at clonal evolution: all the mechanisms, why cells in AML evolve,
and why these clones become resistant to therapy and why different therapies are
needed. The second speaker, who’s from Italy, will be talking about monitoring
of clones in AML, and detection of small clones, and how these clones will then
evolve into relapse in patients. And I will be doing the final talk, looking
very much into the future of how we can target these remaining clones and
patients who are in remission with maintenance therapy to try and delay or
avoid if possible relapses in various situations post-induction and even
post-transplant.

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