Antiphospholipid syndrome – causes, symptoms, diagnosis, treatment, pathology

Antiphospholipid syndrome – causes, symptoms, diagnosis, treatment, pathology

Learning medicine is hard work! Osmosis makes it easy. It takes your lectures and notes to create
a personalized study plan with exclusive videos, practice questions and flashcards, and so
much more. Try it free today! In antiphospholipid syndrome, individuals
produce antiphospholipid antibodies, which attack the phospholipids in the cell membrane
of their own cells, or attack proteins that are bound to those phospholipids. So antiphospholipid syndrome, or APS, is an
autoimmune disease. Antiphospholipid syndrome can be primary or
secondary. Primary antiphospholipid syndrome occurs by
itself, whereas secondary antiphospholipid syndrome occurs with other autoimmune diseases,
especially systemic lupus erythematosus. And just like most autoimmune diseases, antiphospholipid
syndrome is more common in young females. The exact cause of antiphospholipid syndrome
isn’t known, but there are some known genetic and environmental factors. For instance, the HLA-DR7 gene encodes a specific
type of a protein called major histocompatibility complex or MHC class II, which sits on the
surface of the B cell. These surface proteins help activate B cells
so that they can start producing antibodies. Now, having a mutated HLA-DR7 gene predisposes
individuals to activate B cell production of antiphospholipid antibodies. But the presence of the mutated HLA-DR7 gene
alone isn’t enough to develop antiphospholipid syndrome – an environmental trigger must also
be present. There’s a variety of potential triggers
– some common ones include infections – like syphilis, hepatitis C, HIV, and malaria – drugs,
like some cardiovascular drugs – including procainamide, quinidine, propranolol, and
hydralazine – or antipsychotic drugs like phenytoin and chlorpromazine. The main antiphospholipid antibody is anti-beta2-glycoprotein
I, which targets the protein beta2-glycoprotein I, also called apolipoprotein H. This protein
binds to phospholipids and inhibits agglutination which is when platelets clump together to
form blood clots. So when anti-beta2-glycoprotein I binds beta2-glycoprotein
I, it’s not free to do its job, and that leads to clot formation. Another antiphospholipid antibody is anti-cardiolipin,
which targets a lipid in the inner mitochondrial membrane called cardiolipin which binds beta2-glycoprotein
I. Anti-cardiolipin antibodies are also present
in syphilis, and that can cause a false-positive test for syphilis. Autoantibodies might also target blood components. If platelets are targeted, it can lead to
thrombocytopenia, and if red blood cells are targeted it can lead to anemia. So the antiphospholipid antibodies lead to
a hypercoagulable state, meaning that they cause thrombosis or blood clots to form within
arteries and veins. Arterial thrombosis is more common in males,
and can cause a heart attack, stroke, or limb ischemia. In addition, individuals might develop Libman-Sacks
endocarditis, which is where vegetations form, which are a mixture of immune cells and blood
clots – usually on the mitral valve. Venous thrombosis is more common in females,
and typically presents as a deep vein thrombosis. Sometimes, a part of the main clot may break
free and become an embolus, which is where a blood clot travels downstream. Since lung capillaries are very small, this
embolus could get stuck, causing a pulmonary embolism. This is a life-threatening situation because
it literally blocks blood from getting into the lungs to pick up oxygen. Another organ with very small capillaries
is the kidneys, so individuals might develop renal failure. A typical skin finding in antiphospholipid
syndrome is livedo reticularis, which is caused by swelling of the venules due to clots obstructing
them, and appears as a mottled purplish discoloration of the skin. Women affected by antiphospholipid syndrome
tend to have pregnancy-related complications that can lead to a miscarriage. This can occur due to thrombosis leading to
placental infarction. For reasons that aren’t completely understood,
antiphospholipid antibodies are thought to cause neurologic symptoms like headaches and
seizures. In rare cases, antiphospholipid syndrome leads
to rapid organ failure due to generalized thrombosis; this is called catastrophic antiphospholipid
syndrome and can lead to death. Diagnosing antiphospholipid syndrome requires
meeting at least one clinical and one laboratory diagnostic criteria. The two clinical criteria are history of thrombosis,
and pregnancy complications. While the three laboratory criteria are presence
of anticardiolipin, anti-beta2 glycoprotein antibodies, or lupus anticoagulant in the
blood. Now, lupus anticoagulant assay is a funny
name, but it has an explanation. It’s called “lupus” because it was initially
found in people affected by systemic lupus erythematosus. And it’s called “anticoagulant,” because
it acts as an anticoagulant in vitro, even though it’s a procoagulant in vivo. This is because phospholipid-rich platelets,
which are only found in vivo, are needed to activate coagulation factors and cause a clot. In vitro, which is tested using the lupus
anticoagulant assay, the individual’s plasma is mixed with normal pooled plasma and clotting
time is assessed. The pooled plasma doesn’t have many phospholipid-rich
platelets, so individuals with antiphospholipid antibodies end up prolonging the clotting
time. In vivo, there are plenty of phospholipid-rich
platelets around, so the effect is excess clotting. Treatment of antiphospholipid syndrome is
aimed at preventing thrombosis with aspirin to inhibit platelet activation, and avoiding
risk factors, like smoking and oral contraceptives. People that have had a blood clot should also
take warfarin as oral anticoagulant therapy. During pregnancy, warfarin can cross the placenta
and have a toxic effect on the fetus, so it must be replaced by low molecular weight heparin
up until six weeks after delivery. In people with non-thrombotic manifestations
or other associated autoimmune diseases, corticosteroids may be used to help limit the immune response,
and finally, if symptoms are really severe, certain immunosuppressive drugs might be used. All right, as a quick recap, antiphospholipid
syndrome is caused by antibodies, which target the phospholipids in the cell membrane. The three laboratory criteria are presence
of anticardiolipin, anti-beta2 glycoprotein antibodies, or lupus anticoagulant in the
blood. Individuals affected are at higher risk of
thrombosis and pregnancy-related complications. Treatment involves avoiding other risk factors
for thrombosis, as well as taking lifelong aspirin sometimes as prevention of thrombosis. People that have had thrombotic symptoms should
also take warfarin, and during pregnancy, warfarin must be replaced by low molecular
weight heparin.

30 Replies to “Antiphospholipid syndrome – causes, symptoms, diagnosis, treatment, pathology”

  1. Another great rundown! 🙌 It’s worth noting the laboratory studies 📊 inclusive of diagnosis are not routinely run. Also, the aggressive immunosuppressive therapy is usually not indicated unless all other modalities are exhausted. Thanks for pointing this out! ☝️👌

  2. I have been loking for the link between antiphospholid syndrome and the hypercoagulable state and misacrriage for a while but ididnt find explanations now everything is clear thank you very much

  3. Hey I had a question, what's the difference between polyp and papilla? Is it just about the mucous membranes or is anything else involved? If you could please clarify this. Thanks

  4. Why are pulmonary embolisms so dangerous? People don't even need both lungs to live so why is it so bad that blood flow stops in some section of one of the lungs?

  5. Thanks for your videos! Always knew something new from them though I had graduated 9 years ago. But could you please add some photos of skin lesions to your videos? It is hard to recognise any only by description. With real pictures your videos could be way more informative and useful.

  6. According to Robbins and cotran basics of pathology
    Fetal loss does not appear to stem from thrombosis , but rather seems from anybody mediated interference with growth and differentiation of trophoblast, leasing to a failure of placentation. (Pg – 124 )


  8. U guys are doing a phenomenal job…!! These videos are gonna help alot of upcoming doctors..!! Thank u so much….! &All the best…!!

  9. It also takes at least one doctor after 10 years of telling them, MY LEGS HURT! and they did everything including telling me I needed a psychiatrist. I went to the U of Chicago and Mayo. Had I not gone into AFIB for about 8 hrs they never would have done the CT that presented 2 large Pulmonary Embolisms and two legs with multiple clots. A rheumatologist finally put it together back locally. The problem for a man with this disease is unless and have a couple of miscarriages or a stroke,It would not have been found. I was very lucky.(in a not dying kinda way)

  10. I hope more doctors and med students watch this video. I remember going to my primary care doctor after being diagnosed with this and telling him I had this. and he legit had to pull his phone out and look it up on web md. it is just a not very well known condition

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